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When estrogen is prescribed for a postmenopausal woman with a uterusa progestin should also be initiated to reduce the risk of endometrial cancerA woman without a uterus does not need progestinUse of estrogenalone or in combination with a progestinshould be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual womanPatients should be reevaluated periodically as clinically appropriatee.g3-month to 6-month intervalsto determine if treatment is still necessarysee BOXED WARNINGS and WARNINGSFor women who have a uterusadequate diagnostic measuressuch as endometrial samplingwhen indicatedshould be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding.
Using estrogen alone may increase your chance of getting cancer of the uteruswombReport any unusual vaginal bleeding right away while you are using ESTRACEVaginal bleeding after menopause may be a warning sign of cancer of the uterusYour healthcare provider should check any unusual vaginal bleeding to find out the causeDo not use estrogens alone or with progestins to prevent heart diseaseheart attacksstrokesor dementiadecline in brain functionUsing estrogens alone or with progestins may increase your chances of getting heart attacksstrokesbreast cancerblood clotsand dementiaYou and your healthcare provider should talk regularly about whether you still need treatment with ESTRACE vaginal cream.
24Cohen LCoxwell WLMelchione TKoltun WGibson EGupta NRoberts MLow-dose 17-beta estradiol matrix transdermal system in the treatment of moderate-to-severe hot flushes in postmenopausal womenCurr Ther Res Clin Exp 601999534-47.
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