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It is generally agreed that acute episodes of depression require several months or longer of sustained pharmacologic therapySystematic evaluation of Celexa in two studies has shown that its antidepressant efficacy is maintained for periods of up to 24 weeks following 6 or 8 weeks of initial treatment32 weeks totalIn one studypatients were assigned randomly to placebo or to the same dose of Celexa20-60 mg/dayduring obagi tretinoin. maintenance treatment as they had received during the acute stabilization phasewhile in the other studypatients were assigned randomly to continuation of Celexa 20 or 40 mg/dayor placebofor maintenance treatmentIn the latter studythe rates of relapse to depression were similar for the two dose groupssee Clinical Trials under CLINICAL PHARMACOLOGYBased on these limited datait is not known whether the dose of citalopram needed to maintain euthymia is identical to the dose needed to induce remissionIf adverse reactions are bothersomea decrease in dose to 20 mg/day can be considered.
This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.
Combined administration of Celexatitrated to 40 mg/day for 28 daysand the CYP3A4 substrate triazolamsingle dose of 0.25 mgdid not significantly affect the pharmacokinetics of either citalopram or triazolam.
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