At total daily doses ranging from 5 mg to 15 mg, treatment with ditropan tablets was associated with an increase from baseline in mean urine volume per catheterization from 122 ml to 145 ml, an increase from baseline in mean urine volume after morning awakening from 148 ml to 168 ml, and an increase from baseline in the mean percentage of catheterizations without a leaking episode from 43 to 61 .

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Ditropan XL is used to treat symptoms of overactive bladdersuch as frequent or urgent urinationincontinenceurine leakageand increased night-time urination.

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Following oral administration of DITROPANoxybutynin is rapidly absorbed achieving Cmax within an hourfollowing which plasma concentration decreases with an effective half-life of approximately 2 to 3 hoursThe absolute bioavailability of oxybutynin is reported to be about 6range 1.6 to 10.9for the tabletsWide interindividual variation in pharmacokinetic parameters is evident following oral administration of oxybutynin.

DITROPANlike other anticholinergic drugsmay decrease gastrointestinal motility and should be used with caution in patients with conditions such as ulcerative colitisand intestinal atony.

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